Gourmetceuticals home page

Home

Transforming Food with Technology
Lab machine
Lab machine
Lab technicians

Scientific Papers

Gourmetceuticals’ evidence-based culinary technologies are supported by extensive scientific research, Food and Drug Administration (FDA) regulatory status and an exclusive patent portfolio. The company has demonstrated safety and efficacy in clinical trials and is committed to ongoing research, including collaborations with leading research organizations including Harvard, Johns Hopkins and Sloan-Kettering.

PPL-240™ Antioxidant
  1. Siscovick JR, Zapolanski T, Magro C, Carrington K, Prograis S, Nussbaum M, Gonzalez S, Ding W, Granstein RD.
    Polypodium leucotomos inhibits ultraviolet B radiation-induced immunosuppression.
    Photodermatol Photoimmunol Photomed. 2008 Jun;24(3):134-41.
  2. Mulero M, Rodríguez-Yanes E, Nogués MR, Giralt M, Romeu M, González S, Mallol J.
    Polypodium leucotomos extract inhibits glutathione oxidation and prevents Langerhans cell depletion induced by UVB/UVA radiation in a hairless rat model.
    Exp Dermatol. 2008 Feb 27. [Epub ahead of print]
  3. Janczyk A, Garcia-Lopez MA, Fernandez-Peñas P, Alonso-Lebrero JL, Benedicto I, López-Cabrera M, Gonzalez S.
    A Polypodium leucotomos extract inhibits solar-simulated radiation-induced TNF-alpha and iNOS expression, transcriptional activation and apoptosis.
    Exp Dermatol. 2007 Oct;16(10):823-9.
  4. Gonzalez S, Alonso-Lebrero JL, Del Rio R, Jaen P.
    Polypodium leucotomos extract: A nutraceutical with photoprotective properties.
    Drugs Today (Barc). 2007 Jul;43(7):475-85.
  5. Middelkamp-Hup M, Bos J, Rius-Diaz F, Gonzalez S, Westerhof W.
    Treatment of vitiligo vulgaris with narrow-band UVB and oral Polypodium leucotomos extract: a randomized double-blind placebo-controlled study.
    J Eur Acad Dermatol Venereol. 2007 Aug;21(7):942-50.
    PMID: 17659004 [PubMed - in process]
  6. Astner S, Wu A, Chen J, Philips N, Rius-Diaz F, Parrado C, Mihm MC, Goukassian DA, Pathak MA, Gonz·lez S.
    Dietary Lutein/Zeaxanthin Partially Reduces Photoaging and Photocarcinogenesis in Chronically UVB-Irradiated Skh-1 Hairless Mice.
    Skin Pharmacol Physiol. 2007 Aug 24;20(6):283-291 [Epub ahead of print]
    PMID: 17717424 [PubMed - as supplied by publisher]
  7. Philips N, Keller T, Hendrix C, Hamilton S, Arena R, Tuason M, Gonzalez S.
    Regulation of the extracellular matrix remodeling by lutein in dermal fibroblasts, melanoma cells, and ultraviolet radiation exposed fibroblasts.
    Arch Dermatol Res. 2007 Aug 21; [Epub ahead of print]
    PMID: 17710425 [PubMed - as supplied by publisher]
  8. Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C.
    Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis.
    JAMA. 2007 Feb 28;297(8):842-57. Review.
    PMID: 17327526 [PubMed – indexed for MEDLINE]
  9. Middelkamp-Hup MA, Pathak MA, Parrado C, Goukassian D, Rius-Diaz F, Mihm MC, Fitzpatrick TB, Gonzalez S.
    Oral Polypodium leucotomos extract decreases ultraviolet-induced damage of human skin.
    J Am Acad Dermatol. 2004 Dec;51(6):910-8.
    PMID: 15583582 [PubMed – indexed for MEDLINE]
  10. Middelkamp-Hup MA, Pathak MA, Parrado C, Garcia-Caballero T, Rius-Diaz F, Fitzpatrick TB, Gonzalez S.
    Orally administered Polypodium leucotomos extract decreases psoralen-UVA-induced phototoxicity, pigmentation, and damage of human skin.
    J Am Acad Dermatol. 2004 Jan;50(1):41-9.
    PMID: 14699363 [PubMed – indexed for MEDLINE]
  11. Gonzalez S, Pathak MA.
    Inhibition of ultraviolet-induced formation of reactive oxygen species, lipid peroxidation, erythema and skin photosensitization by polypodium leucotomos.
    Photodermatol Photoimmunol Photomed. 1996 Apr;12(2):45-56.
    PMID: 8897589 [PubMed – indexed for MEDLINE]
  12. Gonzalez S, Pathak MA, Cuevas J, Villarrubia VG, Fitzpatrick TB.
    Topical or oral administration with an extract of Polypodium leucotomos prevents acute sunburn and psoralen-induced phototoxic reactions as well as depletion of Langerhans cells in human skin.
    Photodermatol Photoimmunol Photomed. 1997 Feb-Apr;13(1-2):50-60.
    PMID: 9361129 [PubMed – indexed for MEDLINE]

GLPH-1™ Immune Booster
  1. Martín-Vilchez S, Molina-Jiménez F, Alonso-Lebrero JL, Sanz-Cameno P, Rodríguez-Muñoz Y, Benedicto I, Roda-Navarro P, Trapero M, Aragoneses-Fenoll L, González S, Pivel JP, Corbí AL, López-Cabrera M, Moreno-Otero R, Majano PL.
    AM3, a natural glycoconjugate, induces the functional maturation of human dendritic cells.
    Br J Pharmacol. 2008 Jun;154(3):698-708. Epub 2008 Apr 14.
  2. Serrano-Gómez D, Martínez-Nuñez RT, Sierra-Filardi E, Izquierdo N, Colmenares M, Pla J, Rivas L, Martinez-Picado J, Jimenez-Barbero J, Alonso-Lebrero JL, González S, Corbí AL.
    AM3 modulates dendritic cell pathogen recognition capabilities by targeting DC-SIGN. (PDF, 632 KB)
    Antimicrob Agents Chemother. 2007 Jul;51(7):2313-23. Epub 2007 Apr 23.
  3. Alvarez-Mon M, Miravitlles M, Morera J, Callol L, Alvarez-Sala JL.
    Treatment with the immunomodulator AM3 improves the health-related quality of life of patients with COPD.
    Chest. 2005 Apr;127(4):1212-8.
    PMID: 15821197 [PubMed – indexed for MEDLINE]
  4. Perez-Garcia R, Perez-Garcia A, Verbeelen D, Bernstein ED, Villarrubia VG, Alvarez-Mon M.
    AM3 (Inmunoferon) as an adjuvant to hepatitis B vaccination in hemodialysis patients.
    Kidney Int. 2002 May;61(5):1845-52.
    PMID: 11967036 [PubMed – indexed for MEDLINE]
  5. Cordova A, Monserrat J, Villa G, Reyes E, Soto MA.
    Effects of AM3 (Inmunoferon) on increased serum concentrations of interleukin-6 and tumour necrosis factor receptors I and II in cyclists.
    J Sports Sci. 2006 Jun;24(6):565-73.
    PMID: 16608770 [PubMed – indexed for MEDLINE]
  6. Prieto A, Reyes E, Bernstein ED, Martinez B, Monserrat J, Izquierdo JL, Callol L, de LUCAS P, Alvarez-Sala R, Alvarez-Sala JL, Villarrubia VG, Alvarez-Mon M.
    Defective natural killer and phagocytic activities in chronic obstructive pulmonary disease are restored by glycophosphopeptical (inmunoferon).
    Am J Respir Crit Care Med. 2001 Jun;163(7):1578-83.
    PMID: 11401877 [PubMed – indexed for MEDLINE]
  7. Reyes E, Prieto A, de la Hera A, de Lucas P, Alvarez-Sala R, Alvarez-Sala JL, Alvarez-Mon M.
    Treatment with AM3 restores defective T-cell function in COPD patients.
    Chest. 2006 Mar;129(3):527-35.
    PMID: 16537848 [PubMed – indexed for MEDLINE]
  8. Cordova A, Martin JF, Reyes E, Alvarez-Mon M.
    Protection against muscle damage in competitive sports players: the effect of the immunomodulator AM3.
    J Sports Sci. 2004 Sep;22(9):827-33.
    PMID: 15513276 [PubMed – indexed for MEDLINE]
  9. Majano P, Roda-Navarro P, Alonso-Lebrero JL, Brieva A, Casal C, Pivel JP, Lopez-Cabrera M, Moreno-Otero R.
    AM3 inhibits HBV replication through activation of peripheral blood mononuclear cells.
    Int Immunopharmacol. 2004 Jul;4(7):921-7.
    PMID: 15182731 [PubMed – indexed for MEDLINE]
  10. Villarrubia V.G., G. Calvo C., Romero M., Dominguez Carmone M., Sada G.
    Therapeutic impact of AM3 (biological response modifer) on prevention of recurrent acute infections of the respiratory tract. An analysis of 683 persons at high risk.
    Translated and reprinted from: Acta Toxicologica et therapeutica. 1993 Vol. 14(3) July/September